Fibronectin Manufacturers

Fibronectin is a large multidomain glycoprotein found in connective tissue, on cell surfaces, and in plasma and other body fluids . It interacts with a variety of macromolecules including components of the cytoskeleton and the extracellular matrix, circulating components of the blood clotting, fibrinolytic, acute phase and complement systems, and with cell-surface receptors on a variety of cells including fibroblasts, neurons, phagocytes and bacteria. Fibronectin also interacts with itself, forming fibrillar entities whose structure is poorly understood. In addition, it reportedly binds several small molecules such as gangliosides, sugars, and Ca ions. These diverse recognition functions are located on distinct fragments or domains, many of which have been expressed in recombinant form or isolated from proteolytic digests with retention of specific binding properties Fibronectin is involved in many cellular processes, including tissue repair, embryogenesis.