NewEast Biosciences

Contact: Don Wu - Partner
Address: 24 Whitewoods Lane, Malvern, Pennsylvania 19355, USA
Phone: +1-(610)-945-2007 | Fax: +1-(610)-945-2008 | Map/Directions >>

Profile: NewEast Biosciences offers activation assay kits, antibodies for active G proteins, EIA kits, monoclonal antibodies, polyclonal antibodies and protocols. Monoclonal anti-cAMP EIA kit is based on the unique mouse monoclonal anti-cAMP antibody. The monoclonal anti-cAMP antibody displays much higher selectivity over cGMP and ATP, than polyclonal anti-cAMP antibody. It avoids the batch-to-batch variations associated with polyclonal antibody productions from animals, thus providing the reproducibility. Adenosine 3', 5'-cyclic monophosphate (cyclic AMP; cAMP) modulates various physiological functions such as cardiovascular biology, learning & memory, olfaction, immune response, asthma and kidney function (1,2). cAMP is produced from ATP by adenylyl cyclases and is degraded by phosphodiesterases. Stimulation of adenylyl cyclases or inhibition of phosphodiesterases can increase cellular cAMP concentrations. Blockers of adenylyl cyclase-activating receptors and inhibitors of the cAMP-specific phosphodiesterases are used for treating human diseases. Blocking agents for cAMP-increasing beta-adrenergic receptors (beta-blockers) are used for treating abnormal heart rhythms, high blood pressure (hypertension), myocardial infarction and heart failure. Inhibitors of cAMP specific phosphodiesterase types 2 and 4 are being tested for cognition enhancement. Our cAMP ELISA kit is a competitive immunoassay to measure the cAMP levels, either from cell extracts or from in vitro adenylyl cyclase assays. Multi-well plates are coated with goat-anti-mouse serum. cAMP in cell extracts or in in-vitro adenylyl cyclase assays will competitively bind to the monoclonal anti-cAMP antibody in the presence of fixed amounts of cAMP-conjugated horse-radish peroxidase or alkaline phosphatase.

31 Products/Services (Click for related suppliers)  
• β1-Adrenergic Receptor Mouse Monoclonal Antib...• Anti-Active Cdc42 Mouse Monoclonal Antibody• Anti-Active Gα13-GTP Mouse Monoclonal Antibod...
• Anti-Active Gαi Mouse Monoclonal Antibody• Anti-Active Gαo Mouse Monoclonal Antibody• Anti-Active Gαs-GTP Mouse Monoclonal Antibody
• Anti-Active Gαz Mouse Monoclonal Antibody• Anti-Active RhoA Mouse Monoclonal Antibody• Anti-cAMP Mouse Monoclonal Antibody
• Anti-cGMP Mouse Monoclonal Antibody• Anti-Gα13 Rabbit Polyclonal Antibody• Anti-Gαo Rabbit Polyclonal Antibody
• Anti-Gαq Rabbit Polyclonal Antibody• Anti-Gαs Rabbit Polyclonal Antibody• Anti-Orai1 Rabbit Polyclonal Antibody
• Anti-Rac1 Mouse Monoclonal Antibody• Anti-Rac1 Rabbit Polyclonal Antibody• Anti-RhoA Mouse Monoclonal Antibody
• Cdc42 Activation Assay Kit• cGMP ELISA Kits• Custom Monoclonal Antibodies
• Custom Peptide Synthesis• Gαi Activation Assay Kit• Gαo Activation Assay Kit
• Gαs Activation Assay Kit• Gαz Activation Assay Kit• Monoclonal Anti-cGMP EIA Kit
• Monoclonal Antibodies• Peptide Synthesis Services• Phosphospecific Antibodies
• Polyclonal Antibodies

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