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VDM Biochemicals, Inc.

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Contact: Nancy Reilly - Sales
Web: http://www.vdmbio.com
E-Mail:
Address: 5386 Majestic Parkway, Unit-9, Bedford Heights, Ohio 44146, USA
Phone: +1-(440)-786-9400 | Fax: +1-(440)-786-9410 | Map/Directions >>
 
 

Profile: VDM Biochemicals, Inc. offers life science products which are focused on all areas of cancer research, apoptosis, antivirals, antibiotics, enzyme inhibitors, anticoagulants, cannabinoids, cholinergics, histaminergics, intermediates and fine chemicals. Cell-permeable hydroxystryrylacrylonitrile tyrosine kinase inhibitor displays anti-tumor properties. Potently inhibits the kinase activities of JAK2 & Bcr-Abl (IC50 ~100-600 nM and 500-700 nM, respectively), and displays selectivity over other tyrosine kinases, Btk, Lck, Lyn, Src, Syk & ZAP-70 (IC50>5 M). Its in vivo efficacy in cancer reduction which has been successfully demonstrated in NOD-SCID mice engrafted with human Ph+ ALL cells. AM-251 is a 123I radioisotope derivative of the CB1 cannabinoid receptor inverse agonist SR141716A, presenting a radioprobe for in vivo binding studies at the CB1 receptor with a higher affinity (Ki = 7.49 nM) for CB1 than the parent compound (Ki = 11.5 nM). AM-251 has been employed in competitive binding studies to identify CB1 affinity of different cannabimimetic agonists in vivo. Characterization of AM-251-CB1 association with SPECT (single photon emission computed tomography) which has been described.

22 Products/Services (Click for related suppliers)  
• Antiviral Drug Assays• Antiviral Nucleotides• Apoptosis
• Apoptosis Activator I• Apoptosis Activator II• Apoptosis Antibodies
• Apoptosis Antibody Array• Apoptosis Antibody Sampler Kit (Mouse Specific)• Apoptosis Assay Kit
• Apoptosis Assays• Apoptosis Detection Kit• Apoptosis Inhibitors
• Apoptosis Related Antibodies• Cannabinoid Receptor Antisera• Cannabinoid Receptor I Antibody
• Cannabinoid Receptors• Cannabinoids (THC) ELISA Kit• Enzyme Inhibitors
• Enzyme Inhibitors / Activators• Enzymes and Enzyme Inhibitor Antibodies• Screening Assay for Lupus Anticoagulants
• Venom Screening Assay for Lupus Anticoagulants

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