Farmers are looking for advancement and improved animals result from pairing the best bulls and heifers, usually through artificial means. The nature of cloning is that it gives you the same old genetics. Somatic cell nuclear transfer (SCNT) has been used for the cloning of various mammals. However, the rates of a successful, healthy birth are generally poor. To improve cloning efficiency the utilization of an autologous SCNT cloning technique in which the somatic nucleus of a female bovine donor is transferred to its own enucleated oocyte recovered by ovum pick up, in contrast to the routine allogeneic SCNT procedure using oocytes from unrelated females. Embryos derived from autologous SCNT have significantly higher developmental competence than those derived from allogeneic SCNT, especially at the eight-cell (60 vs 44%), morula (45 vs 36%) & blastocyst (38 vs 23%) stages. The pregnancy and birth rates were also higher for the autologous (39 and 23%), compared to the allogeneic (22 & 6%) SCNT groups. Genome-wide histone3-lysine9 methylation profiles reveal that autologous SCNT embryos have less epigenetic defects than the allogeneic SCNTembryos. At least three biotechnology companies are pitching their services to ranchers and dairy farmers. Three of the clones, copies of a famous Holstein named Black Rose, live on farms in Wisconsin dairy country. The companies want to change the way farm animals are bred, helping farmers produce meatier steaks or more milk.